Motif ID: HOX{A5,B5}.p2

Z-value: 1.651


Transcription factors associated with HOX{A5,B5}.p2:

Gene SymbolEntrez IDGene Name
HOXA5 3202 homeobox A5
HOXB5 3215 homeobox B5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA5chr7_-_271832250.243.7e-04Click!
HOXB5chr17_-_466710430.153.1e-02Click!


Activity profile for motif HOX{A5,B5}.p2.

activity profile for motif HOX{A5,B5}.p2


Sorted Z-values histogram for motif HOX{A5,B5}.p2

Sorted Z-values for motif HOX{A5,B5}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A5,B5}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_9268513 56.281 A2M
alpha-2-macroglobulin
chr2_+_17721806 44.208 NM_003385
 VSNL1
visinin-like 1
chr12_-_6798419 39.566 ZNF384
zinc finger protein 384
chr20_+_44650260 36.780 NM_001134771
 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr2_+_17721983 35.949 VSNL1
visinin-like 1
chr11_-_111782447 33.337 NM_001885
 CRYAB
crystallin, alpha B
chr12_-_91572328 31.445 NM_133504
NM_133505
NM_133506
NM_133507
 DCN



decorin



chr1_-_163113129 30.059 RGS5
regulator of G-protein signaling 5
chrM_+_12283 25.465


chr6_+_121756744 24.501 NM_000165
 GJA1
gap junction protein, alpha 1, 43kDa
chr19_-_53757940 23.779 ZNF677
zinc finger protein 677
chr12_-_6798528 21.328 NM_133476
 ZNF384
zinc finger protein 384
chr5_+_17217474 21.201 NM_006317
 BASP1
brain abundant, membrane attached signal protein 1
chr3_+_115342302 20.998 GAP43
growth associated protein 43
chrX_+_135230736 20.987 NM_001159700
 FHL1
four and a half LIM domains 1
chr1_-_183274008 20.723 NM_170706
 NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr1_-_184723952 20.455 EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr11_-_62472901 19.570


chr13_-_45048436 19.088 NM_001243798
 TSC22D1
TSC22 domain family, member 1
chr12_+_54955226 18.985 NM_001165975
 PDE1B
phosphodiesterase 1B, calmodulin-dependent

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 43 entries
enrichment   p-value GO term description
14.20 1.23e-03 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
12.62 3.51e-03 GO:0048880 sensory system development
12.62 3.51e-03 GO:0048892 lateral line nerve development
12.62 3.51e-03 GO:0048895 lateral line nerve glial cell differentiation
12.62 3.51e-03 GO:0048925 lateral line system development
12.62 3.51e-03 GO:0048937 lateral line nerve glial cell development
12.62 3.51e-03 GO:0050935 iridophore differentiation
10.33 1.76e-02 GO:0060600 dichotomous subdivision of an epithelial terminal unit
9.47 3.37e-02 GO:0048846 axon extension involved in axon guidance
9.47 3.37e-02 GO:0090184 positive regulation of kidney development
8.84 1.12e-02 GO:0048485 sympathetic nervous system development
6.82 6.61e-03 GO:0001755 neural crest cell migration
2.71 5.22e-05 GO:0006954 inflammatory response
2.07 2.66e-03 GO:0019226 transmission of nerve impulse
2.07 2.66e-03 GO:0035637 multicellular organismal signaling
2.04 1.74e-02 GO:0007268 synaptic transmission
1.93 1.34e-05 GO:0009611 response to wounding
1.92 9.21e-05 GO:0006952 defense response
1.88 3.99e-02 GO:0051336 regulation of hydrolase activity
1.82 4.11e-03 GO:0007267 cell-cell signaling

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
4.17 1.73e-02 GO:0044309 neuron spine
2.45 3.43e-02 GO:0043025 neuronal cell body
2.37 1.51e-02 GO:0034702 ion channel complex
2.10 1.38e-03 GO:0045202 synapse
1.94 1.80e-02 GO:0044463 cell projection part
1.88 9.70e-09 GO:0005887 integral to plasma membrane
1.86 1.50e-08 GO:0031226 intrinsic to plasma membrane
1.73 2.83e-03 GO:0005615 extracellular space
1.68 2.13e-10 GO:0044459 plasma membrane part
1.61 1.54e-07 GO:0005576 extracellular region
1.60 5.55e-03 GO:0044421 extracellular region part
1.29 8.20e-04 GO:0005886 plasma membrane
1.29 8.93e-04 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
10.52 2.33e-02 GO:0005283 sodium:amino acid symporter activity
1.99 9.51e-03 GO:0015267 channel activity
1.99 1.01e-02 GO:0022803 passive transmembrane transporter activity
1.91 4.87e-02 GO:0022838 substrate-specific channel activity
1.80 3.85e-03 GO:0043565 sequence-specific DNA binding
1.64 7.07e-03 GO:0022857 transmembrane transporter activity